Prevalence and Antimicrobial Resistance Patterns in ESKAPE Pathogens in Iran

Background: The spread of resistant bacteria has caused serious concern worldwide. multidrug-resistant (MDR) and extensive drug-resistant (XDR) limits the choice antibiotics, making available antibiotics less effective. Objectives: This study aimed to investigate resistance patterns seven global threatening organisms announced by Centers for Disease Control Prevention (CDC) one year in Iran, called ESKAPE (Enterococcus spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp.). Methods: Clinical isolates were collected from 10 selective hospitals nine provinces. Antibiotic susceptibility testing was performed according Laboratory Standards Institute each bacterium. Results: A total 5522 bacterial species considered, which 30% ESKAPE. Multidrug-resistant A. baumannii aureus methicillin-resistant (MRSA) most identified Gram-negative -positive bacteria, with frequency 44% 39%, respectively. remaining including E. coli, K. spp. P. Enterococcus had 30%, 32%, 21%, 20%, 22%, Conclusions: determined antibiotic can help determine stewardship. Also, high rates Iran could be alarming healthcare centers not misuse broad-spectrum antibiotics.